Journal
PHYTOCHEMISTRY
Volume 147, Issue -, Pages 1-8Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2017.12.004
Keywords
Sapindus mukorossi; Sapindaceae; Triterpenoid saponins; Anti-fungal activity
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Funding
- National Natural Science Foundation of China [81630093]
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Under the guidance of anti-fungal bioassay, four previously undescribed oleanane-type and one lupane-type triterpenoid saponins, along with twelve known analogues, were isolated from the extract of Sapindus mukorossi pulps. Their structures were determined on the basis of spectroscopic analysis and chemical methods. In vitro biotests, oleanolic acid 3-O-beta-D-xylopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranoside showed inhibitory activity against Trichophyton rubrum with MIC80 value of 8 mu g/mL, while oleanolic acid 3-O-alpha-L-arabinopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranoside exhibited inhibitory activity against both Trichophyton rubrum and Candida albicans with MIC80 values of 8 mu g/mL. (C) 2017 Elsevier Ltd. All rights reserved.
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