Journal
PHYTOCHEMISTRY
Volume 105, Issue -, Pages 135-140Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2014.05.018
Keywords
Prinsepia utilis Royle; Rosaceae; gamma-Hydroxynitrile glucosides; Antibacterial activity
Categories
Funding
- NCET Foundation
- National Natural Science Foundation of China [81230090, 81102778]
- Global Research Network for Medicinal Plants (GRNMP)
- King Saud University
- Shanghai Leading Academic Discipline Project [B906]
- FP7-PEOPLE-IRSES (TCMCANCER Project) [230232]
- Key laboratory of drug research for special environments
- PLA
- Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products [10DZ2251300]
- Scientific Foundation of Shanghai China [09DZ1975700, 09DZ1971500, 10DZ1971700, 12401900501]
- National Major Project of China [2011ZX09307-002-03]
- National Key Technology R&D Program of China [2012BAI29B06]
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gamma-Hydroxynitrile glucosides (prinsepicyanosides A-E) were isolated alongside 11 known compounds from seeds of Prinsepia utilis Royle. Their structures were determined by detailed analysis of NMR and MS spectroscopic data. The relative configuration of prinsepicyanoside C was established by Cu-K alpha X-ray crystallography. Prinsepicyanoside A, osmaronin, and 4-(hydroxylmethyl)-5H-furan-2-one exhibited borderline antibacterial activity against Salmonella gallinarum, Vibrio parahaemolyticus, and Vibrio cholera with MIC values of 30.1, 20.7, and 22.8 mu g/mL, respectively. (C) 2014 Elsevier Ltd. All rights reserved.
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