Journal
PHYTOCHEMISTRY
Volume 104, Issue -, Pages 72-78Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2014.04.014
Keywords
Schisandra chinensis; Schisandraceae; Dibenzocyclooctadiene lignans; Inhibitory activity on lipopolysaccharide; (LPS)-induced NO release
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Funding
- Natural Science Foundation of China [81202891]
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Four dibenzocyclooctadiene lignans, schisanchinins A-D, and 10 known compounds were isolated from the EtOAc extract of fruits of Schisandra chinensis (Turcz.) Baill. Structures of compounds 1-4 were elucidated using a combination of spectroscopic techniques, including MS, UV and IR, NMR (H-1 NMR, C-13 NMR, HMQC, HMBC). The stereochemistry of the chiral centers and the biphenyl configuration were determined using NOESY, as well as analysis of CD spectra. In vitro activity assays showed that 11 of the 14 compounds exhibited inhibitory activity on lipopolysaccharide (LPS)-induced NO release in primary murine BV2 microglia cells. (C) 2014 Elsevier Ltd. All rights reserved.
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