Journal
PHYTOCHEMISTRY
Volume 85, Issue -, Pages 153-160Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.08.014
Keywords
Magnolia officinalis; Magnoliaceae; Structure elucidation; Biphenyl-type neolignan; Anti-inflammatory activity
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Funding
- National Science Council (NSC, Taiwan) [NSC 95-2320-B-127-001-MY3, NSC 98-2320-B-127-001-MY3]
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Reactive oxygen species (ROS) and granule proteases produced by human neutrophils contribute to the pathogenesis of inflammatory diseases. The MeOH extract of the stem bark of Magnolia officinalis showed potent inhibitory effects on superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Five biphenyl-type neolignan derivatives, 5-allyl-5'-(1 ''-hydroxyallyloxy)biphenyl-2,2'-diol, 5,5'-diallyl-2'-(allyloxy)biphenyl-2-ol, 5,5'-diallyl-2'-(3-methylbut-2-enyloxy)biphenyl-2-ol, (E)-5-allyl-3'-(prop-1-enyl)biphenyl-2,4'-diol, and 4-allyl-2-(2'-methylbenzofuran-5'-yl)phenol, have been isolated from the stem bark of M. officinalis, together with 12 known compounds. Several exhibited inhibition (IC50 values <= 10.7 mu M) of superoxide anion generation by human neutrophils in response to fMLP/CB. Others inhibited fMLP/CB-induced elastase release with IC50 values <= 8.76 mu M. (C) 2012 Elsevier Ltd. All rights reserved.
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