4.7 Article

Lanostane triterpenes from cultures of the Basidiomycete Ganoderma orbiforme BCC 22324

Journal

PHYTOCHEMISTRY
Volume 87, Issue -, Pages 133-139

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.11.022

Keywords

Plant pathogenic mushroom; Ganoderma orbiforme; Lanostanes; Antimycobacterial activity; Antiplasmodial activity

Funding

  1. Bioresources Research Network, National Center for Genetic Engineering and Biotechnology (BIOTEC)

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Seven lanostane triterpenoids, ganorbiformins A-G, together with twelve known compounds, were isolated from cultures of the mushroom fungus Ganoderma orbiforme BCC 22324. Ganorbiformin A is an unusual rearranged analog, whereas the other compounds share the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T also exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra (MIC 1.3 mu M). (C) 2012 Elsevier Ltd. All rights reserved.

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