Journal
PHYTOCHEMISTRY
Volume 87, Issue -, Pages 133-139Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.11.022
Keywords
Plant pathogenic mushroom; Ganoderma orbiforme; Lanostanes; Antimycobacterial activity; Antiplasmodial activity
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Funding
- Bioresources Research Network, National Center for Genetic Engineering and Biotechnology (BIOTEC)
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Seven lanostane triterpenoids, ganorbiformins A-G, together with twelve known compounds, were isolated from cultures of the mushroom fungus Ganoderma orbiforme BCC 22324. Ganorbiformin A is an unusual rearranged analog, whereas the other compounds share the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T also exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra (MIC 1.3 mu M). (C) 2012 Elsevier Ltd. All rights reserved.
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