Journal
PHYTOCHEMISTRY
Volume 89, Issue -, Pages 78-88Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2013.01.011
Keywords
Breadfruit tree; Artocarpus altilis; Moraceae; Antioxidant; Tyrosinase; Melanin
Categories
Funding
- National Science Council of Taiwan [NSC 95-2320-B-037-020, NSC 98-2320-B-037-012]
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Flavonoids, 10-oxoartogomezianone (1), 8-geranyl-3-(hydroxyprenyl)isoetin (2), hydroxyartoflavone A (3), isocycloartobiloxanthone (4), and furanocyclocommunin (5), together with 12 known compounds, were isolated from heartwood and cortex of Artocarpus altilis, and their structures were identified by comparing their spectra with those of similar compounds. To identify natural antioxidants and whitening agents, the ability of these prenylated flavonoids was assessed to scavenge the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH center dot), the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(+center dot)) radical cation, and the superoxide anion (O-2(-center dot)), and their abilities to inhibit tyrosinase and melanin production. It was found that compounds 3,4, and artoflavone A (15) had moderate DPPH center dot-scavenging activity, whereas compound 4 exhibited significant ABTS(+center dot)-scavenging activity, and that norartocarpetin (7) and artogomezianone (8) exhibited moderate ABTS(+center dot)-scavenging activity, with compounds 2, 7, and artocarpin (6) displaying good superoxide anion-scavenging activity. In addition, compounds 7, 8, cudraflavone A (14), and artonin M (17), inhibited melanin production by strongly suppressing tyrosinase activity. Compound 6 reduced the melanin content without inhibiting tyrosinase activity. These results suggest that flavonoids isolated from A altilis may be candidate antioxidants and/or skin-whitening agents. However, further investigations are required to determine their mechanisms of action. (C) 2013 Elsevier Ltd. All rights reserved.
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