Journal
PHYTOCHEMISTRY
Volume 87, Issue -, Pages 112-118Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.11.004
Keywords
Lindera strychnifolia; Lauraceae; Sesquiterpene; Eudesmane; HSC-T6 Hepatic stellate cells
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Funding
- Basic Science Research Program through National Research Foundation of Korea [2011-0027077]
- Medical Research Center program through National Research Foundation of Korea [2010-0029480]
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Phytochemical investigation of the roots of Lindera strychnifolia resulted in the isolation of seven sesquiterpene lactones named linderolide G-M (1-7), together with twelve known sesquiterpenes. The structures and relative configurations of 1-7 were determined through spectroscopic observations, and the absolute configurations were defined by CD analysis. Linderolide G (1) and lindestrene (16) showed cytotoxicity against HSC-T6 hepatic stellate cells. (C) 2012 Elsevier Ltd. All rights reserved.
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