Journal
PHYTOCHEMISTRY
Volume 95, Issue -, Pages 360-367Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2013.07.025
Keywords
Huperzia serrata; Lycopodiopsida; Ceriporia lacerate; Polyporaceae; Endophytes; Sesquiterpenes; Nor-sesquiterpenes; Tremulane
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Tremulane sesquiterpenes ceriponols A-K, together with three known ones tremulenediol A, 11,12-dihydroxy-1-tremulen-5-one and conocenol B, were isolated from the cultures of Ceriporia lacerate, a fungal endophyte residing in the stems of the medicinal plant Huperzia serrata. Among these isolates, ceriponol B possessed an unprecedent 12-nortremulane skeleton. The structures of all isolates were elucidated by spectroscopic methods, including MS and NMR (1D and 2D) spectroscopic techniques. The cytotoxic activities of ceriponols A-K were evaluated against three human tumor cell lines (HeLa, HepG2, and SGC 7901). Ceriponols F and K exhibited moderate cytotoxicity against all the tested human cancer cell lines with IC50 values ranging from 32.3 +/- 0.4 to 173.2 +/- 1.5 mu M, while ceriponol G showed slightly better cytotoxicity against a HeLa cell line. (C) 2013 Elsevier Ltd. All rights reserved.
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