Journal
PHYTOCHEMISTRY
Volume 94, Issue -, Pages 249-253Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2013.06.009
Keywords
Euphorbia pekinensis; Euphorbiaceae; Casbane diterpenoid; Cytotoxic activity; Cancer cell lines
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Funding
- National Basic Research Program of China (973 Program) [2011CB505300, 2011CB505303]
- National Natural Science Foundation of China [30672678]
- Program for New Century Excellent Talents in University [NCET-09-0163]
- Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education
- Priority Academic Program Development of Jiangsu Higher Education Institutions [ysxk-2010]
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Four casbane diterpenoids, together with three known related compounds were isolated from the roots of Euphorbia pekinensis. Their structures were elucidated on the basis of spectroscopic studies and comparison with the known related compounds. In addition, the absolute configuration of three compounds was determined by the modified Mosher's method. The isolated compounds were evaluated for their cytotoxic activity against seven human cancer cell lines by a WST-8 assay. (C) 2013 Elsevier Ltd. All rights reserved.
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