Journal
PHYTOCHEMISTRY
Volume 93, Issue -, Pages 199-202Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2013.03.018
Keywords
Endophytic fungus; Cryptosporiopsis sp.; Novel polyketide; Lipoxygenase inhibition; Anti-Bacillus megaterium; TDDFT CD calculations
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Funding
- Higher Education Commission (HEC) of Pakistan
- AvH Foundation, Germany
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An antibiotic polyketide, Cryptosporioptide (1) was isolated from the culture extract of the endophytic fungus Cryptosporiopsis sp. The structure of Cryptosporioptide has been established with the help of 1D (H-1, C-13), 2D NMR (HSQC, HMBC, COSY, NOESY) techniques and mass spectrometry (FABMS, HRFABMS). The absolute configuration was established by means of electronic circular dichroism (ECD). Cryptosporioptide exhibited both lipoxygenase inhibitory and anti-Bacillus megaterium activities. (C) 2013 Elsevier Ltd. All rights reserved.
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