Journal
PHYTOCHEMISTRY
Volume 83, Issue -, Pages 63-69Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.07.013
Keywords
Cathaya argyrophylla; Pinaceae; Labdane diterpene glycosides; Lignan glycosides; Cathargyrosides A-B
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Funding
- National Natural Science Foundation of China [U1032602, 91013002, 30725048, 20972168]
- National New Drug Innovation Major Project of China [2011ZX09307-002-02]
- National Basic Research Program of China [2009CB522300]
- Fund of Chinese Academy of Sciences [KSCX2-YW-R-177]
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Labdane diterpene glycosides cathargyroside A and cathargyroside B. monoterpene glycosides vervenone-10-O-beta-D-glucopyranoside and vervenone-10-O-beta-D-apiofuranosyl-(1 '' -> 6')-beta-D-glucopyranoside, as well as lignan glycosides cedrusinin-4-O-alpha-L-rhamnopyranoside and (+)-cyclo-olivil-9'-O-beta-D-xylopyranoside, along with 39 known compounds, were obtained from the methanol extract of the twigs and leaves of Cathaya argyrophylla. These compounds were identified mainly by analyzing their NMR and MS data. Almost all of these compounds were hitherto unknown in this genus. The isolated compounds were screened against Candida albicans and Staphylococcus aureus for antimicrobial assay, and against 1(562, HT-29, BEL-7402, SGC-7901, B16, BGC-823, U251 and A549 cancer cell lines for cytotoxic activities. One compound showed antimicrobial activity against C. albicans, and four of them displayed cytotoxicity. Similarity analysis on the chemical constituents of the genera Cathaya, Picea and Pinus supported their close phylogenetic relationships. (C) 2012 Elsevier Ltd. All rights reserved.
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