Journal
PHYTOCHEMISTRY
Volume 73, Issue -, Pages 134-141Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.09.014
Keywords
Cymathere triplicata; Brown alga; Oxylipin; Sodium channel inhibition
Categories
Funding
- NIH [NS053398]
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An investigation of the oxylipin chemistry of the temperate brown alga Cymathere triplicata led to the isolation of several secondary metabolites, cymatherelactone (1) and cymatherols A-C (2-4), the latter as their methyl ester derivatives (5-7), which contained cyclopentyl, cyclopropyl, epoxide and lactone rings. Their structures were elucidated using a combination of spectroscopic techniques and synthetic chemistry. Cymatherelactone (1), as well as R- and S-Mosher's esters of its seco acid, exhibited moderate sodium channel blocking activity. (C) 2011 Published by Elsevier Ltd.
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