Journal
PHYTOCHEMISTRY
Volume 78, Issue -, Pages 190-196Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.03.002
Keywords
Coprinus radians; Psathyrellaceae; Diterpenoids; Guanacastane; Radianspenes A-M
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Funding
- National Natural Science Fund for Distinguished Young Scholars [30325044]
- Key Grant of Chinese Ministry of Education [306010]
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Thirteen diterpenoids, named radianspenes A-M (1-13), including three lactams radianspenes J (10), K (11) and L (12) and one dimer radianspene M (13), were isolated from fermentation products of the higher fungal strain Coprinus radians M65. All these compounds possessing guanacastane skeleton were evaluated for antitumor activity using MDA-MB-435 cell line. Radianspene C exhibited inhibitory activity with IC50 of 0.91 mu m. (C) 2012 Elsevier Ltd. All rights reserved.
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