Journal
PHYTOCHEMISTRY
Volume 83, Issue -, Pages 116-124Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.06.013
Keywords
Melodinus yunnanensis; Apocynaceae; Monoterpenoid indole alkaloid; Structure elucidation; Cytotoxicity
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Funding
- National Natural Science Foundation of China [2107298, 21172225, 31170334]
- Young Academic and Technical Leader Raising Foundation of Yunnan Province [2010CI049]
- 973 Program of the Ministry of Science and Technology of P.R. China [2009CB522300]
- Chinese Academy of Sciences (XiBuZhiGuang Project)
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Ten monoterpenoid indole alkaloids, namely meloyine, 19S-methoxytubotaiwine N-4-oxide, 16,19-epoxy-Delta(14)-vincanol, 14 beta-hydroxymeloyunine, meloyunine, Delta(14)-vincamenine N-4-oxide, 16 beta,21 beta-epoxy-vincadine, 14 beta,15 beta-20S-quebrachamine, 3-oxo-voaphylline, 2 alpha,7 alpha-dihydroxy-dihydrovoaphylline, and 32 known alkaloids were isolated from leaves and twigs of Melodious yunnanensis. Their structures were elucidated based on 1- and 2-D NMR, FTIR, UV, and MS spectroscopic data. Meloyine I showed weak cytotoxic activity against four human cancer cell lines: MCF-7 breast cancer, SMMC-7721 hepatocellular carcinoma, HL-60 myeloid leukemia, and A-549 lung cancer. (C) 2012 Elsevier Ltd. All rights reserved.
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