Journal
PHYTOCHEMISTRY
Volume 76, Issue -, Pages 98-105Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.01.007
Keywords
Cryptocarya chingii; Lauraceae; Structure elucidation; Flavonoid; Anti-inflammatory activity; Chemotaxonomic marker
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Funding
- Natural Science Foundation of China [81121062, 81172948, 90813036]
- Ministry of Education [NCET-10-0477]
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Six flavonoids named cryptogiones A-F, and nine known compounds were isolated from an ethanol extract of stems of Cryptocarya chingii. The structures of the compounds were elucidated by interpretation of comprehensive spectroscopic data and X-ray analysis. A majority of these flavonoids contained an acetic acid/lactone moiety, a possible taxonomic marker. Anti-inflammatory effects of the compounds were evaluated using in vitro assays. At 20 mu M concentration, three compounds significantly inhibited TNF alpha-induced NF-kappa B activation and LPS-induced IL-beta expression. (C) 2012 Elsevier Ltd. All rights reserved.
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