Anti-inflammatory flavonoids from Ciyptocarya chingii

Six flavonoids named cryptogiones A-F, and nine known compounds were isolated from an ethanol extract of stems of Cryptocarya chingii. The structures of the compounds were elucidated by interpretation of comprehensive spectroscopic data and X-ray analysis. A majority of these flavonoids contained an acetic acid/lactone moiety, a possible taxonomic marker. Anti-inflammatory effects of the compounds were evaluated using in vitro assays. At 20 mu M concentration, three compounds significantly inhibited TNF alpha-induced NF-kappa B activation and LPS-induced IL-beta expression. (C) 2012 Elsevier Ltd. All rights reserved.