Journal
PHYTOCHEMISTRY
Volume 73, Issue -, Pages 106-113Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.10.001
Keywords
Melia toosendan; Meliaceae; Limonoids; Meliatoosenins E-S; Antiproliferative activity; Cytotoxicity
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Funding
- National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China [2009ZX09301-001]
- National Natural Science Funds for Distinguished Young Scholar [30925043]
- Ministry of Science and Technology [2007DFC31030]
- Shanghai Commission of Science and Technology [08DZ1971401]
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Fifteen limonoids, meliatoosenins E-S (1-15), and to known compounds were isolated from the fruits of Melia toosendan. Their structures were elucidated on the basis of extensive spectroscopic methods including DEPT, HSQC, HMBC, H-1-H-1 COSY, and ROESY experiments. All the compounds were evaluated for antiproliferative activity using A-549 and HL-60 cell lines. (C) 2011 Elsevier Ltd. All rights reserved.
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