Journal
PHYTOCHEMISTRY
Volume 81, Issue -, Pages 117-125Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.06.005
Keywords
Pterospermum acerifolium; Acylated phytosterol glucoside; Phytoceramides; Osteogenic activity; Osteoblast
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Funding
- Indian Council of Medical Research, New Delhi, India
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Phytochemical investigation of seed coats of Pterospermum acerifolium afforded two phytoceramides (1, 2) and two acylated phytosterol glucosides (3, 4) together with five known compounds (5-9). Their structures were elucidated on the basis of extensive spectroscopic analysis using 1D, 2D NMR and Mass spectrometry. Compounds 1, 2, 3, and 4 were assessed for their osteogenic activity using primary cultures of osteoblasts harvested from neonatal rat calvaria. Among these compounds, 1 and 2 markedly stimulated osteoblast differentiation assessed by alkaline phosphatase production and osteoblast mineralization by alizarin red-S staining. (C) 2012 Elsevier Ltd. All rights reserved.
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