Journal
PHYTOCHEMISTRY
Volume 84, Issue -, Pages 177-183Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.08.011
Keywords
Antrodia camphorata; Polyporales; Fomitopsidaceae; Cinnamomun kanehirai Hay; Lauraceae; Chinese herb; Lanostane-type triterpenoids; Fungal sterols; Camphosterol A
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Funding
- China Medical University [CMU97-217 CMU-222]
- National Science Council of the Republic of China
- Taiwan Department of Health [DOH 100-TD-B-111-004, DOH 101-TD-B-111-004]
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Four lanostane triterpenes, 3,7,11-trioxo-5 alpha-lanosta-8,24(E)-dien-26-oic acid, methyl 11 alpha-3,7-dioxo-5 alpha-lanosta-8,24(E)-dien-26-oate, methyl 3,7,11,12,15,23-hexaoxo-5 alpha-lanost-8-en-26-oate, and ethyl 3,7,11,12,15,23-hexaoxo-5 alpha-lanost-8-en-26-oate, two sterols, (14 alpha,22E)-14-hydroxyergosta-7,22-diene-3,6-dione and a steroid named as camphosterol A were isolated from a mixture of fruiting bodies and mycelia of solid cultures of Antrodia camphorata. The H-1 and C-13 NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, HMQC, HMBC and NOESY sequences. Six compounds were evaluated for cytotoxicity against several human tumor cell lines, all of which has moderate activity. (c) 2012 Elsevier Ltd. All rights reserved.
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