Journal
PHYTOCHEMISTRY
Volume 72, Issue 9, Pages 923-928Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.03.011
Keywords
Hexagonia speciosa; Basidiomycete; Cyclohexanoids; Speciosins L-T
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Funding
- National Basic Research Program of China (973 Program) [2009CB522300]
- National Natural Science Foundation of China [30830113]
- State Key Laboratory of Drug Research [SIMM0812KF-03]
- MOST [2009ZX09501-029, 2009ZX09501-013]
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Nine oxygenated cyclohexanoids, speciosins L-T (1-9) as well as a 5H-furan-2-one metabolite, 5'-O-acetylaporpinone A (10), together with known analogs, speciosins A. B, D, E, F, I and K (11-17), and aporpinone A (18), were isolated from a scale-up cultures of the basidiomycete Hexagonia speciosa. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR. Speciosin B (12) showed significant cytotoxicity against several tumor cell lines with IC(50) values in the range 0.23-3.30 mu M. (C) 2011 Elsevier Ltd. All rights reserved.
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