Journal
PHYTOCHEMISTRY
Volume 72, Issue 11-12, Pages 1436-1442Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.04.014
Keywords
Emericella; Endophytic fungus; Aegiceras corniculatum; Myrsinaceae; Isoindolone derivatives; Antiviral activity
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Funding
- Chinese National Science Fund [30973627, 30772640]
- State Oceanic Administration [2010418022-3]
- program for Changjiang Scholars and Innovative Research Team in University [IRT0944]
- Shandong Provincial Natural Science Fund [ZR2009CZ016]
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Chemical investigation of the endophytic fungus Emericella sp. (HK-ZJ) isolated from the mangrove plant Aegiceras corniculatum led to isolation of six isoindolones derivatives termed as emerimidine A and B and emeriphenolicins A and D, and six previously reported compounds named aspernidine A and B, austin, austinol, dehydroaustin, and acetoxydehydroaustin, respectively. Their structures were elucidated on the basis of NMR spectroscopic evidence while the anti-influenza A viral (H1N1) activities of eight compounds were also evaluated using the cytopathic effect (CPE) inhibition assay. (C) 2011 Elsevier Ltd. All rights reserved.
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