Journal
PHYTOCHEMISTRY
Volume 72, Issue 6, Pages 508-513Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.01.010
Keywords
Harrisonia perforata; Simaroubeaceae; Limonoids; Single-crystal X-ray diffraction; Epimer
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Funding
- Chinese Academy of Sciences [KSCXR-YW-N-008]
- Ministry of Science and Technology [2009CB522300, 2009CB940900]
- 863 program or State hightech development plan [2007AA021505]
- Yunnan Tobacco company [08A09]
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Eight limonoids (1-8) including three A, B and D-seco-16-nor-type ones, 5,6-dehydrodesepoxyharperforin C2 (1), harrpernoid B (2), and its C-OS epimer, harrpernoid C (3), along with six known compounds (9-14), were isolated from fruits of Harrisonia perforata. Extensive spectroscopic analysis was used to elucidate their structures and stereochemistries. Further confirmation of structures of 1 and 2 were obtained by single-crystal X-ray diffraction. Limonoids (1-8) were evaluated for their anti-tobacco mosaic virus activity and in vitro cytotoxicity against A549 and HL60 cell lines; only compound 2 showed weak activity. (C) 2011 Elsevier Ltd. All rights reserved.
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