Journal
PHYTOCHEMISTRY
Volume 72, Issue 11-12, Pages 1443-1452Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.04.005
Keywords
Endiandra kingiana; Lauraceae; Bcl-xL; Anti-apoptotic proteins; Kingianins; Polyketides
Categories
Funding
- ICSN-CNRS
Ask authors/readers for more resources
An in vitro biological screening of Malaysian plants allowed the selection of several species with a significant binding affinity for the antiapoptotic protein Bcl-xL. The chemical investigation of Endiandra kingiana led to the isolation of a series of polyketides named kingianins A-N, having a pentacyclic carbon skeleton described for the first time in nature. Fourteen compounds were isolated as racemic mixtures, and characterized by mass spectrometryand extensive one- and two-dimensional NMR spectroscopy. The (-) and (+) enantiomers of kingianins A and G-L were separated using chiral HPLC, and the absolute configuration of four of them was clearly established by CD analysis. The levorotatory enantiomers showed the more potent binding affinity for Bcl-xL with Ki ranging from 1.0 to 12 mu M. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available