Journal
PHYTOCHEMISTRY
Volume 72, Issue 8, Pages 769-772Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.02.003
Keywords
Plocamium suhrii; Plocamium cornutum; Halogenated monoterpenes; Cytotoxicity; Esophageal cancer
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Funding
- Rhodes University
- South African National Research Foundation
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Five known (1, 2, 4, 6 and 7) halogenated monoterpenes together with 1Z,3R*,4S*,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene (3) and (3R*,4S*)-3,4,6,7-tetrachloro-3,7-dimethylocten-1-ene (5) were isolated from the red macroalga Plocamium suhrii and their structures deduced from their spectroscopic data. The seven compounds from P. suhrii together with five related compounds from Plocamium cornutum have been evaluated for their cytotoxic effects on an esophageal cancer cell line (WHCO1). Compounds 1-6 showed greater cytotoxicity in this assay as compared to the known anticancer drug cisplatin. (C) 2011 Elsevier Ltd. All rights reserved.
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