Journal
PHYTOCHEMISTRY
Volume 71, Issue 2-3, Pages 254-261Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2009.10.004
Keywords
Entada rheedii; Mimosaceae; Triterprene saponins; Rheediinosides A-B; Antioxidant; Antiproliferative
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Funding
- IFS (International Foundation for Science, Stockholm, Sweden) [F/3976-2]
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Two triterpenoid saponins have been isolated from the seed kernels of Entada rheedii. Their structures have been established using 1D- and 2D-NMR and mass spectrometry as 3-O-beta-D-xylopyranosyl-(1 -> 3)-O-alpha-L-arabinopyranosyl-(1 -> 6)-2-acetylamino-2-deoxy-beta-D-glucopyranosylentagenic acid 28-O-beta-apiofuranosyl-(1 -> 3)-beta-D-xylopyranosy1-(1 -> 2)-beta-D-glucopyranoside (Rheediinoside A, 1) and 3-O-beta-D-glucopyranosyl-(1 -> 3)-O-[beta-D-xylopyranosyl-(1 -> 3)-alpha-L-arabinopyranosyl-(1 -> 6)]-2-acetylamino-2-deoxy-beta-D-glucopyranosylentagenic acid 28-O-beta-apiofuranosyl-(1 -> 3)-beta-D-xylopyranosyl-(1 -> 2)-beta-D-glucopyranoside (Rheediinoside B, 2). Compounds 1 and 2 were tested for their antiproliferative activity against T98G, A431, PC3 and B16-F1 cell lines, and further for their antioxidant properties. Moderate cytotoxic potency and antioxidant properties were found for these compounds whereas Rheediinoside B was in all assays more active than Rheedimoside A. (C) 2009 Elsevier Ltd. All rights reserved.
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