Journal
PHYTOCHEMISTRY
Volume 71, Issue 11-12, Pages 1298-1304Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2010.05.022
Keywords
Andrographolide; Andrographis paniculata; Diterpene lactone; Biosynthesis; Deoxyxylulose phosphate pathway; Mevalonic acid pathway
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Andrographolide, a diterpene lactone, is isolated from Andrographis paniculata which is well known for its medicinal properties. The biosynthetic route to andrographolide was studied using [1-C-13]acetate, [2-C-13]acetate and [1,6-C-13(2)]glucose. The peak enrichment of eight carbon atoms in the C-13 NMR spectra of andrographolide suggested that deoxyxylulose pathway (DXP) is the major biosynthetic pathway to this diterpene. The contribution of the mevalonic acid pathway (MVA) is indicated by the observed C-13-labeling pattern, and because the labeling patterns indicate a simultaneous contribution of both methyl erythritol phosphate (MEP) and MVA pathways it can be deduced that cross-talk occurs between plastids and cytoplasm. (C) 2010 Elsevier Ltd. All rights reserved.
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