Journal
PHYTOCHEMISTRY
Volume 71, Issue 7, Pages 816-822Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2010.02.007
Keywords
Macleaya microcarpa; Papaveraceae; Structure determination; Dihydrobenzophenanthridine alkaloids; Maclekarpine A-E; Cytotoxic activity
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Five dihydrobenzophenanthridine alkaloids, named as maclekarpine A-E, were isolated from the roots of Macleaya microcarpa, together with 10 known benzophenanthridine/dihydrobenzophenanthridine derivatives and a known amide. Their structures were determined on the basis of spectroscopic methods. The relative configuration of maclekarpine A was solved by X-ray single-crystal diffraction, which also contributed to the establishment of the relative configuration of maclekarpine B and C, as well as the assignment of the absolute configuration of maclekarpine A-C with aid of their CD curves. Cytotoxicity of the isolated compounds against five human tumor cell-lines was evaluated, with some having activity with IC(50) values ranging from 0.1 to 3.5 mu M. (C) 2010 Elsevier Ltd. All rights reserved.
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