Journal
PHYTOCHEMISTRY
Volume 71, Issue 1, Pages 110-116Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2009.09.024
Keywords
Antifungal agents; Depsidones; Botryosphaeria rhodina; Endophytes; Polyketides; Symbiosis
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Funding
- Ministry of Higher Education, Egypt
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An endophytic fungus (Botryosphaeria rhodina) was isolated from the stems of the medicinal plant Bidens pilosa (Asteraceae) that is known for its anti-inflammatory, antiseptic and antifungal effects. The ethyl acetate extract of the fungal isolate exhibits significant antifungal activity as well as potent cytotoxic and antiproliferative effects against several cancer cell lines. Activity-guided fractionation resulted in the isolation of a complex of four depsidones, botryorhodines A-D and the auxin indole carboxylic acid. Botryorhodine A and B show moderate to weak cytotoxic activities against HeLa cell lines with a CC50 Of 96.97 mu M and 36.41 mu M, respectively. In addition, they also show antifungal activity against a range of pathogenic fungi such as Aspergillus terreus (MIC 26.03 mu M for botryorhodine A and 49.70 mu M for B) and the plant pathogen Fusarium oxysporum (MIC 191.60 mu M for botryorhodine A and 238.80 mu M for B). A potential role of the endophyte in modulating fungal populations living within or attacking the host plant is discussed. (C) 2009 Elsevier Ltd. All rights reserved.
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