Journal
PHYTOCHEMISTRY
Volume 71, Issue 14-15, Pages 1749-1755Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2010.07.004
Keywords
Erythrophleum fordii; Leguminosae; Cassaine diterpenoid-diterpenoid amide dimers; Cassaine diterpenoid amides; Cytotoxicity
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Funding
- National Found for Distinguished Young Scholars [30625040]
- National Natural Science Foundation of China [90713039]
- National Science and Technology Project of China [2009ZX09311-004]
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Detailed phytochemical investigation from the leaves of Erythrophleum fordii resulted in the isolation of 13 compounds, including three cassaine diterpenoid-diterpenoid amide dimers (1, 3 and 5), and seven cassaine diterpenoid amides (6 and 8-13), together with three previously reported ones, erythrophlesins D (2), C (4) and 3 beta-hydroxynorerythrosuamide (7). Compounds 1, 3 and 5 are further additions to the small group of cassaine diterpenoid dimers represented by erythrophlesins A-D. Their structures were determined by analysis of extensive one- and two-dimensional NMR experiments and ESIMS methods. Cytotoxic activities of the isolated compounds were tested against HCT-8, Bel-7402, BGC-823, A549 and A2780 human cancer cell lines in the MIT test. Results showed that compounds 1 and 3-5 exhibited significantly selective cytotoxic activities (IC(50) < 10 mu M) against these cells, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
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