A lipase inhibitor monoterpene and monoterpene glycosides from Monarda punctata

An 80% acetone extract of Monarda punctata showed an inhibitory effect on lipase activity in isolated mouse plasma in vitro and carvacrol was obtained as the active constituent. It had an IC50 value of 4.07 mM in vitro and suppressed elevations in blood triacylglycerol levels in olive oil-loaded mice. Furthermore, from the whole plant, 22 compounds were isolated. Six monoterpene glycosides (3-8), a flavone glucuronide (9), and other known compounds were identified based on the results of spectroscopic analyses. (C) 2010 Elsevier Ltd. All rights reserved.