Journal
PHYTOCHEMISTRY
Volume 71, Issue 13, Pages 1579-1585Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2010.06.005
Keywords
Ganoderma lucidum; Triterpenoids; Cytotoxicity; Structure and activity relationship
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Funding
- National Natural Science Foundation of China (NNSFC) [30701077]
- ministry of Sciences and Technology of China [2006BAI08B03-03]
- National Science and Technology Major Project Key New Drug Creation and Manufacturing Program, China [2009ZX09308-005, 2009ZX09311-001, 2009ZX09502-020]
- Ministry of Science and Technology of the People's Republic of China
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A systematic study of the metabolites in Ganoderma lucidum led to isolation of 43 triterpenoids, six of them (1-6) are hitherto unknown. The structures of the latter were elucidated on the basis of spectroscopic studies and comparison with the known related compounds. All of the compounds were assayed for their inhibitory activities against human HeLa cervical cancer cell lines. Some compounds exhibit significant cytotoxicity, and their structure-activity relationships are discussed. (C) 2010 Elsevier Ltd. All rights reserved.
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