Oleanane-type triterpene oligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak

The methanolic extract from the pericarps of Sapindus rarak DC. was found to show pancreatic lipase inhibitory activity (IC50 = ca. 614 mu g/mL). From the extract, oleanane-type triterpene oligoglycosides, rarasaponins I-III (1-3), and raraoside A (4), were isolated together with 13 known saponins and four known sesquiterpene glycosides. Among them, several saponin constituents including rarasaponins I (1, IC50 = 131 mu M) and II (2, 172 mu M), and raraoside A (4, 151 mu M) inhibited pancreatic lipase activity, which were stronger than that of theasaponin E-1 (270 mu M). (C) 2009 Elsevier Ltd. All rights reserved.