Journal
PHYTOCHEMISTRY
Volume 70, Issue 15-16, Pages 1621-1637Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2009.07.030
Keywords
Monoterpene synthase; Sesquiterpene synthase; Terpene synthase reaction mechanism; Site-directed mutagenesis; Terpene synthase structure; Structure-function correlation
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Funding
- European Commission [QLRT-2001-01930, MRTN-CT-2003-504720]
- German Science Foundation [DE8372-2]
- Max Planck Society
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The multitude of terpene carbon skeletons in plants is formed by enzymes known as terpene synthases. This review covers the monoterpene and sesquiterpene synthases presenting an up-to-date list of enzymes reported and evidence for their ability to form multiple products. The reaction mechanisms of these enzyme classes are described, and information on how terpene synthase proteins mediate catalysis is summarized. Correlations between specific amino acid motifs and terpene synthase function are described, including an analysis of the relationships between active site sequence and cyclization type and a discussion of whether specific protein features might facilitate multiple product formation. (C) 2009 Elsevier Ltd. All rights reserved.
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