Journal
PHYTOCHEMISTRY
Volume 70, Issue 5, Pages 597-600Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2009.02.010
Keywords
Plocamium cornutum; Plocamiaceae; Antimalarial; Halogenated monoterpene
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Funding
- National Research Foundation
- Rhodes University
- Mellon Foundation
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in our continuing search for antimalarial leads from South African marine organisms we have examined the antiplasmodial organic extracts of the endemic marine red alga Plocamium cornutum (Turner) Harvey. Two new and three known halogenated monoterpenes were isolated and their structures determined by standard spectroscopic techniques. The 3,7-dimethyl-3,4-dichloro-octa-1,5,7-triene skeleton is common to all five compounds. Interestingly, compounds bearing the 7-dichloromethyl substituent showed significantly higher antiplasmodial activity toward a chloroquine sensitive strain of Plasmodium falciparum. (C) 2009 Elsevier Ltd. All rights reserved.
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