Journal
PHYTOCHEMISTRY
Volume 70, Issue 9, Pages 1161-1165Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2009.06.008
Keywords
Aeollanthus rydingianus; Labiatae; Aerial parts; Isopimarane diterpenoids; Acyloxy-isopimarane derivatives; Antibacterial activity
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Funding
- Portuguese Fundacao para a Ciencia e a Tecnologia [SFRH/BD/19250/2004]
- Spanish Comision Interministerial de Ciencia y Tecnologia [CTQ2006-15279-C03-02]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/19250/2004] Funding Source: FCT
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Four acyloxy-isopimarane derivatives along with two known isopimarane diterpenoids, the flavone cirsimaritin and the sterols P-sitosterol and stigmasterol were isolated from the aerial parts of Aeollanthus rydingianus. The structures of the compounds were established on the basis of spectroscopic analysis and chemical evidence. The isolated substances were screened for antimicrobial activity against Gram-positive and Gram-negative bacteria and a yeast strain. 19-Acetoxy-7,15-isopimaradien-3 beta-ol and 7,15-isopimaradien-19-ol showed minimum inhibitory concentration (MIC) values of 3.90-15.62 mu g/ml for Staphylococcus aureus and of 7.81 mu g/ml for Enterococcus hirae. (C) 2009 Elsevier Ltd. All rights reserved.
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