4.7 Article

A web-based resource for the Arabidopsis P450, cytochromes b5, NADPH-cytochrome P450 reductases, and family 1 glycosyltransferases (http://www.P450.kvl.dk)

Journal

PHYTOCHEMISTRY
Volume 70, Issue 17-18, Pages 1940-1947

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2009.08.024

Keywords

Bioinformatics; Web resource; P450; UGT; beta-Glycosidases; CPR; Secondary metabolism; Evolution; Multi-gene family

Funding

  1. UGTs
  2. VKR foundation
  3. Danish National Research Foundation

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Gene and genome duplication is a key driving force in evolution of plant diversity. This has resulted in a number of large multi-gene families. Two of the largest multi-gene families in plants are the cytochromes P450 (P450s) and family I glycosyltransferases (UGTs). These two families are key players in evolution, especially of plant secondary metabolism, and in adaption to abiotic and biotic stress. In the model plant Arabidopsis thaliana there are 246 and 112 cytochromes P450 and UGTs, respectively. The Arabidopsis P450, cytochromes b(5), NADPH-cytochrome P450 reductases, and family I glycosyltransferases website (http://www.P450.kvl.dk) is a sequence repository of manually curated sequences, multiple sequence alignments, phylogenetic trees, sequence motif logos, 3D structures, intron-exon maps, and customized BLAST datasets. (C) 2009 Elsevier Ltd. All rights reserved.

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