Journal
PHYTOCHEMISTRY
Volume 69, Issue 5, Pages 1273-1278Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2007.10.030
Keywords
Penicillium; endophytic fungi; Aegiceras corniculatum; Myrsinaceae; polyketides; cytotoxicity
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Four polyketides, leptosphaerone C (1), penicillenone (2), arugosin 1 (3) and 9-demethyl FR-901235 (4), as well as five known compounds, bacillosporin A (5), bacillosporin C (6), sequoiamonascin D (7), sequoiatone A (8), and sequoiatone B (9) were isolated from the Penicillium sp. JP-1, an endophytic fungus isolated from Aegiceras corniculatum. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectroscopic analyses. Compound 1 showed cytotoxicity against A-549 cells with an IC50 value of 1.45 mu M, while compound 2 showed cytotoxicity against P388 cells with an IC50 value of 1.38 mu M. (c) 2007 Elsevier Ltd. All rights reserved.
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