Journal
PHYTOCHEMISTRY
Volume 69, Issue 16, Pages 2820-2825Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2008.09.007
Keywords
Grateloupia elliptica; Halymeniaceae; alpha-Glucosidase; Bromophenol; Inhibitor; Diabetes mellitus; Red alga
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Funding
- Korea Science and Engineering Foundation [F01-2004-00010006-0]
- Japan Society for the Promotion of Science
- Ministry of Education, Science and Technology, Republic of Korea
- National Research Foundation of Korea [핵06B2509] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Diabetes mellitus is a most serious and chronic disease whose incidence rates are increasing with incidences of obesity and aging of the general population over the world. One therapeutic approach for decreasing postprandial hyperglycemia is to retard absorption of glucose by inhibition of alpha-glucosidase. Two bromophenols, 2,4,6-tribromophenol and 2,4-dibromophenol, were purified from the red alga Grateloupia elliptica. IC50 values of 2,4,6-tribromophenol and 2,4-dibromophenol were 60.3 and 110.4 mu M against Saccharomyces cerevisiae alpha-glucosidase, and 130.3 and 230.3 mu M against Bacillus stearothermophilus alpha-glucosidase, respectively. In addition, both mildly inhibited rat-intestinal sucrase (IC50 of 4.2 and 3.6 mM) and rat-intestinal maltase (IC50 of 5.0 and 4.8 mM). Therefore, bromophenols of G. elliptica have potential as natural nutraceuticals to prevent diabetes mellitus because of their high ot-glucosidase inhibitory activity. (C) 2008 Elsevier Ltd. All rights reserved.
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