Journal
PHYTOCHEMISTRY
Volume 69, Issue 1, Pages 276-287Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2007.07.005
Keywords
Gelonium aequoreum; Euphorbiaceae; ent-abietane diterpenes; gelomulides K-X; cytotoxicity
Categories
Funding
- NCI NIH HHS [CA17625] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA017625] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) cancer cell lines. (C) 2007 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available