Journal
PHYTOCHEMISTRY
Volume 69, Issue 14, Pages 2621-2626Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2008.08.005
Keywords
Nodulisporium; Pleosporales; Marine-derived fungi; Bioactive compounds; Cytotoxic activity; Antimalarial compounds; Tetronic acid; Tetramic acid
Categories
Funding
- Center for Toxicology, Environmental Health
- Management of Toxic Chemicals
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Nodulisporacid A (1) was isolated from a marine-derived fungus Nodulisporium sp. CRIF1, while vermelhotin (5) was obtained from an unidentified fungus CRI247-01 (a member of the Order Pleosporales). Both 1 and 5 occurred as equilibrium E/Z mixtures. Ester derivatives (2 and 3) and vermelhotin (5) showed cytotoxic activity against eleven cancer cell lines. Nodulisporacid A (1) and vermelhotin (5) exhibited moderate antiplasmodial activity. (C) 2008 Elsevier Ltd. All rights reserved.
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