Journal
PHYTOCHEMISTRY
Volume 69, Issue 13, Pages 2495-2500Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2008.07.005
Keywords
Hydrolithon reinboldii; Tydemania expeditionis; Alga; Cancer; Marine; Unsaturated fatty acid
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Funding
- US National Institutes of Health's International Cooperative Biodiversity Groups [U01-TW007401-01]
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Phytochemical analysis of Fijian populations of the green alga Tydemania expeditionis led to the isolation of two unsaturated fatty acids, 3(zeta)-hydroxy-octadeca-4(E),6(Z),15(Z)-trienoic acid (1) and 3(zeta)-hydroxy-hexadeca-4(E),6(Z)-dienoic acid (2), along with the known 3(zeta)-hydroxy-octadeca-4(E),6(Z)-dienoic acid (4), Investigations of the red alga Hydrolithon reinboldii led to identification of a glycolipid, lithonoside (3), and five known compounds, 15-tricosenoic acid, hexacosa-5,9-dienoic methyl ester, beta-sitosterol, 10(S)-hydroxypheophytin A, and 10(R)-hydroxypheophytin A. The structures of 1-3 were elucidated by spectroscopic methods (1D and 2D NMR spectroscopy and ESI-MS). Compounds 1, 2, and 4, containing conjugated double bonds, demonstrated moderate inhibitory activity against a panel of tumor cell lines (including breast, colon, lung, prostate and ovarian cells) with IC50 values ranging from 1.3 to 14.4 mu M. The similar cell selectivity patterns of these three compounds suggest that they might act by a common, but unknown, mechanism of action. (c) 2008 Elsevier Ltd. All rights reserved.
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