Journal
PHYTOCHEMISTRY
Volume 69, Issue 7, Pages 1597-1603Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2008.01.005
Keywords
Hydrocotyle sibthorpioides; umbelliferae; oleanane-type triterpenoidal saponin; cytotoxicity; chemotaxonomy
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Oleanane-type triterpenoidal saponins, hydrocosisaponins A-F (1-6), along with a known saponin, hydrocotyloside VII (7), were isolated from Hydrocotyle sibthorpioides. Their structures were established on the basis of spectroscopic analyses including NMR spectroscopic techniques ((13)C, (1)H, COSY, HMQC, HMBC, TOCSY and NOESY). Biological evaluation established that saponins possessing four sugar units (three D-glucoses and one L-arabinose) (4-7) exhibited moderate cytotoxicity against KB, Daoy and WiDr human tumor cell lines. (C) 2008 Published by Elsevier Ltd.
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