Journal
PHYTOCHEMISTRY
Volume 69, Issue 2, Pages 451-456Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2007.07.019
Keywords
Eysenhardtia subcoriacea; Fabaceae; coumarins; flavan-3-ols; 3-(2 '-hydroxy-4 ',5 '-methylendioxyphenyl)-6-(3 ''-hydroxymethyl-4 ''-hydroxybut-2 ''-enyl)-7-hydroxycoumarin; subcoriacin; antioxidant activity; reduced glutathione
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Antioxidant activity (AOA) assay-guided chemical analysis, using a rat pancreas homogenate model, of aerial parts from Eysenhardtia subcoriacea, led to isolation of the new compound subcoriacin (3-(2'-hydroxy-4',5'-methylendioxyphenyl)-6-(3 ''-hydroxymethyl-4 ''-hydroxybut-2 ''-enyl)-7-hydroxycoumarin) together with the known substances: (+)-catechin, (-)-epicatechin, (+)-afzelechin, eriodictyol, (+)-catechin 3-O-beta-D-galactopyranoside and quercetin 3-O-beta-D-galactopyranoside as bioactive constituents. The structure of the compound was determined from ID and 2D NMR spectroscopic analyses. Additional known constituents were characterized. The bioactive compounds showed also moderate to strong radical scavenging properties against diphenylpicrylhydrazyl radical (DPPH). In addition, subcoriacin, (+)-catechin, (-)-epicatechin and (+)-afzelechin improved the reduced glutathione levels in rat pancreatic homogenate. (C) 2007 Elsevier Ltd. All rights reserved.
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