Journal
PHYSIOLOGY & BEHAVIOR
Volume 105, Issue 2, Pages 209-214Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2011.08.020
Keywords
Cocaine; Females; Males; Reinstatement; Relapse; Stress
Categories
Funding
- National Institute on Drug Abuse [DA16511, DA21690, 1F32 DA025411]
- NIH [C06 RR015455]
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Significant sex differences have been demonstrated in clinical and preclinical studies of cocaine addiction, with some of the most consistent differences noted in regard to the role of stress and craving. The current study examined stress-induced reinstatement of cocaine seeking in male and female rats in an animal model of relapse using corticotropin-releasing factor (CRF) administration. Both male and female rats demonstrated increased cocaine seeking in response to CRF. CRF-induced reinstatement was highly variable across both male and female rats, and further analysis revealed a subpopulation that was particularly sensitive to CRF (high responders). Female high responders displayed significantly increased responding to CRF compared to males. Individual differences in stress responsivity could thus contribute to the likelihood of relapse, with females showing greater heterogeneity to stress-induced relapse. (C) 2011 Elsevier Inc. All rights reserved.
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