Journal
PHYSIOLOGY & BEHAVIOR
Volume 94, Issue 5, Pages 637-642Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2008.04.005
Keywords
leptin receptor; STAT3; hypothalamus; Jak2; feeding
Categories
Funding
- NIDDK NIH HHS [R01 DK078056, R01 DK056731-10, R01 DK057768, R01 DK057768-09, R01 DK056731, R01 DK078056-01A1] Funding Source: Medline
Ask authors/readers for more resources
The adipose tissue-derived hormone, leptin, acts via its receptor (LepRb) in the brain to regulate energy balance and neuroendocrine function. Parsing the biology of leptin requires understanding LepRb signaling and the roles for specific signaling pathways in neural and physiological leptin action. Since the leptin acts via a broadly distributed network of LepRb-expressing neurons, understanding the function of each of these LepRb neural populations will also be crucial. Here, we review the status of knowledge regarding the molecular mediators of leptin action and the neural substrate via which leptin acts to regulate physiologic processes. (C) 2008 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available