Journal
PHYSIOLOGY
Volume 29, Issue 4, Pages 250-264Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00059.2013
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Funding
- National Institutes of Health [AG-013038, HL-107120, HL-107105, AG-000279, AG-039210, AG-044031, TR-001082]
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Endothelial dysfunction develops with age and increases the risk of age-associated vascular disorders. Nitric oxide insufficiency, oxidative stress, and chronic low-grade inflammation, induced by upregulation of adverse cellular signaling processes and imbalances in stress resistance pathways, mediate endothelial dysfunction with aging. Healthy lifestyle behaviors preserve endothelial function with aging by inhibiting these mechanisms, and novel nutraceutical compounds that favorably modulate these pathways hold promise as a complementary approach for preserving endothelial health.
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