Journal
PHYSIOLOGY
Volume 29, Issue 2, Pages 141-149Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00040.2013
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Funding
- British Heart Foundation [PG/10/75/28537, RG/12/3/29423]
- NSF-NIH CRCNS program [NIH R01 AA-18060]
- Wellcome Trust
- British Heart Foundation [PG/10/75/28537, RG/12/3/29423] Funding Source: researchfish
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Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search for therapies that have the potential to offer greater efficacy and tolerability compared with current treatments.
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