4.5 Review

cAMP and Mitochondria

Journal

PHYSIOLOGY
Volume 28, Issue 3, Pages 199-209

Publisher

AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00004.2013

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Funding

  1. National Institutes of Health [GM-088999]
  2. Muscular Dystrophy Association [GM-62328, HD-059913, NS-55255]
  3. EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD059913] Funding Source: NIH RePORTER
  4. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM062328, R01GM088999] Funding Source: NIH RePORTER
  5. NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS055255] Funding Source: NIH RePORTER

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Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial proteins have just started to be investigated, and the presence of cAMP-generating enzymes and PKA inside mitochondria is still controversial. Here, we discuss the role of cAMP in regulating mitochondrial bioenergetics through protein phosphorylation and the evidence for soluble adenylyl cyclase as the source of cAMP inside mitochondria.

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