Journal
PHYSIOLOGY
Volume 28, Issue 6, Pages 380-390Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00024.2013
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Funding
- National Heart, Lung, and Blood Institute [HL-092961]
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Fibroblast migration is essential to normal wound healing and pathological matrix deposition in fibrosis. This review summarizes our understanding of how fibroblasts navigate 2D and 3D extracellular matrices, how this behavior is influenced by the architecture and mechanical properties of the matrix, and how migration is integrated with the other principle functions of fibroblasts, including matrix deposition, contraction, and degradation.
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