Journal
PHYSIOLOGY
Volume 27, Issue 6, Pages 343-350Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00034.2012
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Funding
- National Heart, Lung, and Blood Institute [PO1 HL-085577, RO1 HL-75573, RO1 HL-104535]
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Although the function of the sarcoplasmic/endoplasmic reticulum (SR/ER) in cardiac contractile calcium handling is well established, its roles in protein synthesis, folding, and quality control in cardiac myocytes are not as clear. This review explores evidence suggesting that, in cardiac myocytes, protein synthesis and contractile calcium handling may be physically and functionally integrated.
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