Journal
PHYSIOLOGY
Volume 27, Issue 4, Pages 200-212Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00015.2012
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Funding
- National Institute of Neurological Disorders and Stroke
- National Institutes of Health
- Venetian Institute of Molecular Medicine and Institute of Neuroscience
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In mammals, smell is mediated by odorant receptors expressed by sensory neurons in the nose. These specialized receptors are found both on olfactory sensory neurons' cilia and axon terminals. Although the primary function of ciliary odorant receptors is to detect odorants, their axonal role remains unclear but is thought to involve axon guidance. This review discusses findings that show axonal odorant receptors are indeed functional and capable of modulating neural connectivity.
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